Research

The research program of the Feringa group is focussed on synthetic organic chemistry. Over the years a unique expertise in stereochemistry has been acquired. Inspired by nature's principles of molecular assembly, recognition, transport, motion and catalysis, the goal is to exploit the full potential of synthetic chemistry to create new structures and functions. A major part of the research is directed towards nanotechnology and novel functional materials, such as molecular switches and motors. A second part of the program deals with the development (and application in chemical biology) of novel stereoselective synthesis methods and asymmetric catalysis. Control of chirality is the guiding principle in both programs.

Scientific program of the Feringa group

from molecules to molecular systems

The mission of the research programme in the Feringa group is to exploit the full potential of synthetic chemistry to create new structures, functions and chemical systems. Inspired by Nature's principles of molecular recognition, assembly, catalysis, transport and motion, the goal is to design novel functional (supra-) molecular materials as well as to develop new catalysts and synthetic methodology.

Three major areas of interest can be distinguished:
Molecular Nanoscience: with particular emphasis on the control of dynamics including switches, translational and rotary molecular motors, self-assembly and multifunctional nanosystems (read more).
Synthesis and catalysis: which a focus on the development of asymmetric catalysis, catalytic oxidation and coupling reactions and application of novel catalytic methods in synthesis (read more).
Biohybrid systems: the design of responsive biohybrid materials, artificial membranes, photopharmacology and methodology for biomolecular imaging (read more).

Chirality is a leading theme and over the years a broad expertise in fundamental aspects of chirality has been built including new asymmetric synthesis methodology, chiroptical phenomena, chiral amplification, and dynamic and supramolecular chirality. The research in the group has a strong multidisciplinary character.

Research programs

Subprogram 1: Molecular Nanoscience (Center for Systems Chemistry, Gravity program functional molecular systems and top research school Zernike Institute for Advanced Materials). The focus is currently on four major challenges e.g.:

Molecular switching: to trigger or address in a fully reversible manner a variety of functions. The projects range from the design of systems for molecular information storage and molecular electronics to responsive (smart) surfaces (read more).
Molecular organization: how to control and reversibly change assembly and organization at different hierarchical levels, in supramolecular materials and self-assembled monolayers on surfaces. Particular emphasis is on liquid crystal materials, low molecular weight gels and nanotube formation.
Molecular motors: how to control motion by exploring synthetic molecular motors. Light-driven rotary motors and catalytic motors are studied. The focus is on autonomous motion, the quest to make motors to perform work and the integration of molecular motors in nano-mechanical systems (read more).
Molecular systems: how to integrate various functions in dynamic complex molecular systems. A key challenge is the design of chemical systems out of thermodynamic equilibrium i.e. kinetically driven multifunctional systems.

Our systems approach to complex dynamic functions and materials in the past decade and the recent establishment of the Center for Systems Chemistry has greatly stimulated a strong multidisciplinary and cooperative effort at the interphase between chemistry, molecular biology, physics and surface sciences.